you can break rooms and big areas of your home into little chunks; then deal with the chunks and liberally throw away.
for example, our dog's cage has been sitting in this spot, unused for at least six months. since then, it has become an informal table whereupon bottles, boxes and bags have settled. next to the cage is a fan that was displaced from another part of our home. i found that i began to use it last summer, but during the winter months, it too has been unused. then you have the tote-box, some gatorade bottles and a few shirts i've been meaning to donate.
today, i just decided to GET IT DONE.
the dog cage, while not used often, does get used a few times a year. i put it in storage.
the tote box, along with a few other tote boxes that were in the same room, are actively being used. i put them in a proper area too.
the bottles were stowed in the pantry (don't know how they ended up in this room).
the fan was moved to another wall.
the clothes were put into the "to donate" bag.
while not much was tossed out in this area, other areas of our home that are chunk-able, will have a lot to be discarded.